Design of Medical Studies
Design of medical studies, with emphasis on randomized controlled clinical trials.
Bias elimination, controls, treatment assignment and randomization, precision, replication, power and sample size calculations, stratification, and ethics.
| Instructors: | ||
|---|---|---|
| Susanne May, Ph.D. | Scott S. Emerson, M.D., Ph.D. | |
| Associate Professor | Professor | |
| Department of Biostatistics | Department of Biostatistics | |
| University of Washington | University of Washington | |
| Office: | HSB F653 | HSB F673 |
| Phone: | 206-616-6342 (Biostat) | 206-616-6678 (Biostat) |
| 206-685-1302 (ROC) | 206-685-1302 (ROC) | |
| Email: | sjmay@uw.edu | semerson@uw.edu |
| Office hours: | (By appointment) | (By appointment) |
Times and Places
Lectures : MW 8:00am - 9:20am HSB T625
Syllabus and General Information
BIOST 524 Syllabus (pdf)
Supplemental Materials
Clinical Trials: Overview and Terminology (NRC Missing Data in RCT Report Appendix A (pdf))
Frequentist evaluation of group sequential clinical trial designs (pdf)
Sample size computation (pdf)
October 2009 short course materials
Course Materials
| Date | Handouts | Videos | HW Assigned | HW Due | Miscellaneous |
|---|---|---|---|---|---|
| Mon, 28 Mar | Lecture 1a | Lecture | Minutes from class discussion | ||
| Wed, 30 Mar | Lecture 1b | Lecture | Homework 1 (Key) (Excel) | "Discerning Hype..." | |
| Mon, 4 Apr | Lecture 2 | Lecture | Homework 1 | ||
| Wed, 6 Apr | Lecture 3 | Lecture | Homework 2 | Protocol Template | |
| Mon, 11 Apr | Lecture | Homework 2 | NSCLC Articles | ||
| Wed, 13 Apr | Lecture | Homework 3 | |||
| Mon, 18 Apr | HW 3 Discussion | Lecture | Homework 3 | ||
| Wed, 20 Apr | Lecture 4 | Lecture | Homework 4 Proposals (Excel) | ||
| Mon, 25 Apr | Lecture | Homework 4 (part I) | |||
| Wed, 27 Apr | Lecture 6 | Lecture | Homework 4 (part II) | ||
| Mon, 2 May | Lecture 7 | Lecture | |||
| Wed, 4 May | Lecture 8 | Lecture | |||
| Mon, 9 May | Lecture | ||||
| Wed, 11 May | Lecture 9 | Lecture | |||
| Mon, 16 May | |||||
| Wed, 18 May | |||||
| Mon, 23 May | |||||
| Wed, 25 May | |||||
| Wed, 1 Jun |