sc ptid tx start age sex stage dxpbc well prur sob splen spiders telang physedem alkphos ast alt bili alb ptsec ptinr crt chol wbc plt crtclr mayo fvc fvcpred dlco dlcopred endo avgstage avgfib weight height 1 1001 MTX 2/9/1994 34 Female 3 12/1/1989 8 16 1 1 1 1 1 397 53 66 0.5 4.1 11 0.9 0.8 234 4.5 181 96 2.859 3.49 101 24.4 92 2 2.2 1.4 69.4 161.8 1 1002 MTX 6/22/1994 44 Female 4 7/15/1986 4 4 1 1 1 1 1 312 46 40 0.6 4.6 11 0.9 0.8 213 6.5 304 108 3.078 3.42 111 23.4 98 2 3.8 3 88.2 158.8 1 1003 MTX 4/10/1995 54 Female 3 1/1/1984 4 4 1 1 1 1 1 248 75 73 0.6 4 11 0.9 0.8 225 7.2 260 93 3.861 3.06 112 15.8 74 2 1.8 1 50.8 152.4 1 1004 MTX 2/7/1994 52 Female 2 1/1/1990 8 4 2 1 1 1 1 203 30 30 0.5 4.3 12 1 0.6 164 8.5 622 95 3.648 3.19 100 20.7 87 2 1.6 0.8 67.6 163.8 1 1005 MTX 2/2/1994 48 Female 2 1/1/1981 8 16 1 1 1 1 1 393 56 73 1.2 4.1 11 0.9 0.7 245 7 186 104 4.168 3.67 103 24.8 96 1 2 1 50.8 154.9 1 1006 Placebo 1/26/1994 59 Female 2 11/1/1991 4 4 1 1 1 2 1 267 38 36 0.4 3.9 11 0.8 0.9 203 3.5 158 71 3.767 2.84 114 15.6 79 2 2.4 1.4 47.5 149.1 1 1007 Placebo 3/28/1994 58 Female 3 3/1/1989 4 4 1 1 1 1 1 98 27 22 0.5 4.4 12 1.1 0.8 218 7.1 337 67 3.824 2.81 99 21.9 102 2 2.8 1.4 50 157.5 1 1008 MTX 5/16/1994 59 Female 3 1/1/1988 4 8 1 1 1 1 2 187 30 14 0.5 3.6 11 0.9 0.8 219 4.3 124 80 4.593 2.54 84 15.9 71 2 2.8 2 70.1 162.6 1 1009 Placebo 2/9/1994 54 Female 2 1/30/1990 8 12 1 1 1 1 1 274 59 73 0.5 4.1 12 1 0.7 268 9.4 411 112 3.847 2.85 95 18.5 81 2 1.6 0.8 65.3 156 1 1012 MTX 6/22/1994 65 Female 3 6/15/1989 8 8 1 1 1 1 1 220 67 71 0.5 3.6 11 0.9 0.9 286 4.8 237 60 4.397 2.55 100 12.7 65 2 3 1.8 64.9 153.9 1 1013 Placebo 2/9/1994 51 Female 2 6/1/1991 4 4 2 1 1 1 1 106 38 46 0.6 4.3 11 0.8 0.9 312 6.9 314 86 3.561 3.34 109 22.8 98 2 1 0 69.9 160.5 1 1014 MTX 8/1/1994 56 Female 3 12/7/1990 4 4 1 1 1 1 1 304 86 84 0.6 4.1 12 1.1 0.7 319 10 275 89 4.083 3.48 117 19.6 88 2 2 1 59.6 161.3 1 1015 Placebo 4/18/1994 54 Female 3 5/1/1993 14 14 1 1 1 1 1 145 21 16 0.8 4.4 11 0.9 0.8 224 6.9 200 73 4.3 2.97 99 15.5 68 2 3 1.8 49.1 160 1 1016 Placebo 8/15/1994 59 Female 3 6/1/1986 12 4 1 2 1 2 1 322 93 97 1.1 4.6 12 1.1 0.7 212 3.9 135 81 4.437 2.69 86 18.5 81 1 2.8 2 60.9 165.1 1 1018 Placebo 8/22/1994 53 Female 4 12/15/1992 8 8 1 1 1 1 1 266 83 67 1.4 3.7 12 1 0.6 284 6.1 133 116 4.964 3.34 97 16.6 66 1 3.2 2.4 61.7 170 1 1020 MTX 10/5/1994 32 Female 3 9/1/1992 8 12 1 1 1 1 1 276 74 108 1.6 4.2 11 0.9 0.9 475 6.2 307 94 4.163 4.26 126 24.9 95 2 3 2.2 87.8 160.8 1 1022 Placebo 3/16/1994 67 Female 3 10/1/1987 4 12 1 1 1 1 1 323 34 31 0.4 3.7 12 1 0.8 274 4.1 331 82 4.419 3.07 92 15.8 67 2 2.6 1.5 56.2 172.7 1 1024 Placebo 5/4/1994 47 Female 1 4/1/1993 4 12 1 1 1 1 1 148 41 69 0.6 3.8 12 1 0.9 152 7.4 276 76 3.925 2.99 94 19.5 81 2 1 0 51.7 161.3 1 1026 Placebo 7/13/1994 47 Female 3 5/1/1988 4 12 1 1 1 1 1 220 95 119 1 4 11 0.9 0.8 196 3.8 134 92 4.033 3.61 106 19.6 78 2 1.8 1 55.3 165.1 1 1027 Placebo 11/21/1994 63 Male 3 8/1/1988 4 4 1 1 1 1 1 95 19 19 0.5 4.2 12 0.9 1 211 9.9 320 97 4.137 4.38 103 16.1 59 2 1 0 87.1 175.3 1 1028 Placebo 10/5/1994 55 Female 3 2/13/1989 4 4 1 1 1 2 1 468 57 35 0.9 4.1 12 1 0.9 167 3.7 102 84 4.398 3.75 97 16.1 60 1 2.8 1.8 74.8 180.01 1 1029 MTX 10/17/1994 47 Female 3 8/1/1992 8 4 1 1 1 1 1 309 50 41 0.6 3.6 11 0.8 0.7 218 7.9 303 96 3.854 3.35 104 14.9 61 2 3.2 1.8 82.3 160 1 1030 Placebo 6/8/1994 52 Female 3 10/1/1988 4 4 1 1 1 1 1 427 73 73 0.8 4.2 11 0.9 0.8 257 4.5 244 83 3.91 2.68 91 13.2 58 2 3.8 2.6 49.7 154 1 1037 MTX 9/28/1994 51 Male 2 10/1/1992 4 8 1 1 1 1 1 370 20 21 1.2 3.7 12 0.9 1.3 134 5.4 364 91 4.752 5.36 114 31.8 106 2 1 0.5 74.8 175.3 1 1038 Placebo 11/9/1994 43 Female 4 8/1/1992 8 8 1 2 2 2 1 235 61 52 1.6 3.2 13 1 0.7 189 3.7 104 107 5.248 3.96 109 20.6 77 1 4 3 76.7 170.2 1 1039 MTX 12/12/1994 49 Female 3 1/22/1994 8 8 2 1 1 1 1 146 25 26 0.3 3.8 13 1.2 0.7 181 7 242 106 3.589 2.75 89 15.5 66 2 2.6 1.4 58.3 157.5 1 1040 MTX 12/5/1994 48 Female 3 2/1/1994 4 4 1 1 1 1 2 131 18 16 0.2 3.8 11 0.8 0.9 222 7.8 266 104 3.229 2.84 76 17.1 64 2 1 0.2 106.4 174.8 1 1043 MTX 6/26/1995 56 Female 1 7/7/1993 4 4 1 1 1 1 1 69 19 19 0.6 3.8 11.4 1 1 203 4 190 91 4.154 3.37 108 18.9 81 2 1 0 77 162.6 1 1044 MTX 7/10/1995 68 Female 4 8/1/1977 4 4 1 1 1 1 1 157 29 25 0.7 4 11 1 0.7 229 4 126 115 4.541 3.99 112 16.9 59 2 4 2.8 64 171.5 1 1045 Placebo 6/21/1995 56 Female 4 1/1/1982 8 8 1 1 2 2 1 78 28 19 0.6 3.7 11.7 1 0.8 249 8.8 261 95 4.283 3.38 114 12.6 56 2 3 2 65.4 162.6 1 1049 Placebo 4/12/1995 45 Female 3 12/10/1993 8 8 2 1 1 1 1 530 202 149 0.4 3.5 11 0.8 0.9 245 4 157 77 3.494 3.88 108 15.4 58 2 3 2 62.1 172.7 1 1055 Placebo 10/25/1995 64 Female 3 1/14/1992 4 8 1 1 1 1 1 105 28 35 1 3.8 11 0.9 0.8 171 5.9 239 84 5.255 2.84 97 17.1 79 2 1.8 0.8 69.9 160 1 1057 Placebo 3/25/1996 44 Male 3 3/15/1995 4 4 1 1 1 1 1 219 35 54 1 4 11.3 1 0.9 205 4.7 142 102 3.98 3.9 76 20.4 63 2 3.25 2.25 87 175 1 1058 MTX 8/14/1996 49 Female 3 12/5/1995 4 4 1 1 1 1 1 208 19 18 0.7 3.8 11 0.9 1 237 6.6 264 71 3.93 3.1 112 16.1 74 2 1.75 1.25 71.2 152.4 1 1060 Placebo 5/5/1997 53 Female 1 10/15/1996 4 4 1 1 1 1 1 103 19 19 0.4 3.8 11 0.8 0.7 228 6.5 297 95 4.028 3.69 112 21.2 88 2 1.5 0.5 67.4 166.4 1 1062 MTX 6/2/1997 41 Female 3 3/16/1996 4 8 1 1 1 1 1 103 23 15 0.5 3.9 11 0.9 0.8 179 4.4 204 123 3.259 4.2 115 22.7 84 2 3 2 97.5 170.2 1 1063 Placebo 7/2/1997 54 Female 2 6/1/1996 8 16 1 1 1 1 1 274 31 22 1.2 3.8 12 1 0.8 290 5.7 259 72 5.231 2.53 91 20.2 94 2 1.5 0.75 76.2 154.9 1 1064 MTX 5/28/1997 66 Female 3 10/21/1996 4 4 1 1 1 1 1 75 24 15 0.4 4 13 1.1 1.1 208 4.3 269 92 4.373 2.74 102 15.6 77 2 1.75 0.5 72.5 155.7 1 1065 MTX 6/25/1997 48 Female 2 7/17/1995 8 12 1 1 1 1 1 471 62 79 1.8 3.5 11 0.9 0.9 334 3.4 136 77 4.921 3.42 96 16.5 64 2 2.5 1.5 82.6 165.9 1 1066 Placebo 8/2/1994 59 Female 3 1/1/1986 4 4 1 1 1 1 1 133 24 30 0.4 4.1 10.8 0.7 1 204 6.5 161 79 3.596 2.55 96 15.9 80 1 3.4 2.2 59 152.4 1 1067 MTX 3/18/1994 50 Female 3 10/4/1990 4 4 1 1 1 1 1 165 35 31 0.6 4 11.6 1 1 219 7.1 213 116 3.831 4.22 113 25.7 83 2 2.8 1.8 94.1 177.8 2 2001 Placebo 4/26/1994 44 Female 4 2/16/1989 5 4 1 2 2 2 1 123 29 30 0.8 4.3 12.4 1 1 182 3.5 93 97 3.823 3.93 105 18.5 86 1 3.8 2.8 58.5 167.6 2 2002 Placebo 4/26/1994 55 Female 4 11/1/1985 -9 4 1 1 1 1 1 143 28 28 0.8 3.6 12.3 1 0.7 197 5.3 168 70 4.683 2.71 95 17 79 1 MISSING MISSING 67.6 156.2 2 2003 MTX 4/26/1994 36 Female 3 10/23/1990 4 4 1 1 1 1 1 159 28 50 0.8 3.5 12 1 1 210 5.9 178 73 3.954 4.52 121 26.5 104 1 3 1.8 64 172.7 2 2005 MTX 4/26/1994 56 Female 3 12/1/1980 8 8 1 1 1 1 1 115 21 24 0.5 3.9 11.2 0.9 1 266 8.2 169 62 3.887 2.99 105 9 45 2 3.8 2.6 68.3 158.2 2 2006 Placebo 1/3/1995 38 Female 3 8/26/1993 8 16 1 2 1 1 1 230 61 51 1.1 3.6 12.4 -0.9 0.8 191 6.5 183 73 4.316 3.56 110 16.5 71 1 2.4 1.6 74.4 156.2 2 2007 MTX 4/26/1994 55 Female 3 12/1/1987 9 4 1 2 1 1 1 261 59 60 0.6 4.2 12 -0.9 0.9 230 6.2 309 73 3.983 2.53 93 -9 -9 2 2 0.8 58 154.94 2 2017 MTX 1/3/1995 53 Female 4 10/1/1991 6 4 1 1 2 1 1 118 41 37 0.4 4.2 11.1 -0.9 0.8 233 6.9 244 72 3.367 2.52 90 11.8 64 2 MISSING MISSING 60.3 152.4 2 2018 Placebo 1/3/1995 51 Female 3 12/1/1986 6 13 1 2 1 1 1 517 35 41 1 4.3 11.1 0.9 1 297 7.8 293 83 4.027 3.53 112 12.6 52 2 3 1.6 76.7 162.6 2 2021 MTX 1/3/1995 40 Female 3 10/1/1991 4 5 1 2 2 2 1 455 64 86 0.9 4 11.7 1 0.9 332 6.5 252 255 3.815 3.41 109 18.6 81 1 3 1.8 56.29 154.94 2 2022 MTX 1/3/1995 44 Female 3 5/1/1994 4 5 1 1 1 1 1 245 46 54 0.5 4.1 11.6 -0.9 0.7 274 7.3 219 78 3.376 4.06 114 22 89 2 2 1 74.8 168.9 2 2023 Placebo 1/6/1995 34 Female 1 10/1/1993 7 8 1 1 2 1 1 251 33 62 0.8 4.5 11.4 1 1 286 6.9 441 116 3.118 3.38 98 17.1 76 2 2.8 1.2 -99.9 -99.9 2 2024 MTX 1/3/1995 48 Female 2 9/30/1988 4 16 1 1 1 1 1 501 131 144 2.7 4.1 10.4 0.8 0.8 367 3.9 235 92 4.741 3.11 97 21.4 93 2 1.8 0.8 58.3 162.1 2 2038 Placebo 4/30/1996 60 Female 4 7/27/1987 -9 -9 1 1 1 1 1 142 30 33 1.2 4.8 12 0.9 0.9 296 5.4 247 70 4.444 2.94 92 20 85 1 2.25 1.5 85.5 167.6 2 2056 Placebo 11/1/1995 52 Male 2 6/1/1989 4 4 1 1 1 1 1 271 68 129 1 4.3 10 0.8 1.1 298 5.3 169 116 3.818 5.42 99 40.1 122 2 2.2 1.2 102.1 190.5 2 2058 Placebo 2/23/1998 44 Female 3 4/25/1997 8 12 1 1 1 1 1 258 49 54 0.9 4.2 14 1.1 0.8 260 9.2 262 150 4.274 3.27 85 29.3 101 2 2.25 1.25 88.5 172.7 3 3001 Placebo 6/6/1994 56 Female 4 5/1/1984 4 4 1 1 1 1 1 349 70 84 0.7 4 11 0.9 0.8 376 5.4 188 88 4.503 2.52 88 17.2 92 2 3.8 2.8 62.1 160 3 3003 MTX 6/6/1994 64 Female 3 9/21/1982 8 16 1 1 1 1 1 320 34 50 0.4 3.4 10 0.7 0.6 241 5.4 204 97 4.082 2.43 94 14.9 85 2 1.6 0.4 69.7 154.9 3 3005 Placebo 6/6/1994 54 Female 3 10/10/1984 4 4 1 1 1 1 1 443 70 77 0.7 4 11 0.8 1 225 7 263 82 3.995 2.87 104 16.8 91 2 3 1.6 67.1 154.9 3 3006 MTX 9/19/1994 64 Female 4 7/24/1980 8 12 1 2 1 1 1 211 47 63 0.8 3.8 11 0.8 0.7 214 5.9 172 84 4.631 2.12 85 14.7 85 3 2.4 1.6 56.8 152.4 3 3018 MTX 3/20/1995 44 Female 4 10/22/1992 4 4 1 1 1 1 1 338 53 70 0.4 4.1 10 0.7 0.7 213 3.6 216 145 2.789 3.38 105 16.6 82 2 2.6 1.6 70.3 157.5 3 3021 MTX 5/10/1995 51 Female 4 4/6/1994 5 9 1 1 2 1 1 158 51 32 1 3.9 11.5 0.8 0.7 143 4.9 145 150 4.359 4.19 111 21.8 103 1 3.2 2.2 77.7 172.69 3 3022 Placebo 3/20/1995 49 Female 3 10/15/1980 4 4 1 1 1 1 2 123 24 32 0.2 4.4 11.4 0.8 0.6 201 6.8 289 132 2.982 2.92 92 17.7 89 2 1.6 1 64.9 162.61 3 3023 Placebo 3/27/1995 45 Female 2 6/11/1984 8 8 1 1 1 1 1 91 30 27 0.4 4.2 11.4 0.8 0.7 214 4.6 267 148 3.118 3.51 109 20.1 100 2 1.4 0.8 95.7 157.51 3 3049 MTX 8/16/1996 63 Male 2 9/14/1993 4 8 1 1 1 1 1 127 28 27 0.5 3.7 12.6 1 0.9 164 6.3 227 107 4.573 5.74 125 25.5 96 2 1 0 75.7 180.3 3 3051 Placebo 9/2/1997 41 Male 3 11/6/1996 7 4 1 1 1 1 1 276 29 32 0.7 4.4 12 1 0.8 -9 7.4 298 129 3.454 4.57 87 26 86 2 3 2.25 107.3 182.91 4 4001 Placebo 6/2/1994 60 Male 4 9/16/1992 6 4 1 1 2 1 1 140 34 38 0.2 4.1 10.7 1 0.7 202 4.8 106 152 3.01 3.68 76 22.8 83 2 4 3 96 180.3 4 4003 MTX 4/28/1994 47 Female 3 3/2/1990 4 4 1 1 1 1 1 204 26 28 0.5 3.8 9.5 0.9 0.9 237 5.8 220 85 3.21 4 114 19.2 92 2 MISSING MISSING 75 167.6 4 4005 Placebo 7/28/1994 67 Female 3 7/19/1990 4 4 1 2 1 1 2 194 30 24 0.5 4.4 10.8 1 1 176 4.9 113 65 4.354 2.47 88 20.9 117 2 2.2 1 72 160 4 4007 MTX 2/18/1994 32 Female 3 5/20/1988 4 12 1 1 1 1 1 272 60 99 0.6 4.4 10.5 0.9 0.6 303 4.3 164 134 2.651 3.28 103 28.8 139 2 3 2 42.6 152.4 4 4008 Placebo 1/27/1994 56 Female 2 5/1/1992 6 4 1 1 2 1 1 206 35 35 0.3 3.9 10.3 0.9 1 198 6.5 244 88 3.672 3.69 110 17.9 90 2 2 0.6 66 167.6 4 4009 MTX 6/30/1994 50 Female 3 12/10/1990 4 12 1 1 1 1 1 210 28 37 0.3 4.3 9.5 0.9 0.7 250 6.4 218 90 2.569 2.7 90 14.8 77 2 2.8 2.2 50.8 154.9 4 4010 Placebo 5/15/1994 51 Male 3 6/27/1989 4 4 1 1 1 1 1 99 44 65 0.5 4.2 11.3 1 1.1 139 4.9 140 79 3.526 5.18 107 30.7 106 2 2.4 1.4 87.7 175.3 4 4014 MTX 5/19/1994 62 Female 2 3/19/1992 4 -9 1 1 1 1 1 101 20 20 0.3 3.9 12.7 1.1 0.8 245 7.8 301 82 3.975 2.97 102 16.2 88 2 1.8 1.2 52.1 170.18 4 4018 Placebo 4/28/1994 67 Female 2 2/18/1992 4 4 1 1 2 2 1 158 16 25 0.3 4.2 10.4 0.9 0.7 268 10.4 330 132 3.507 2.73 88 16.4 88 2 1.2 0.4 66.2 166.9 4 4019 Placebo 10/20/1994 59 Female 2 1/7/1994 6 8 1 2 1 1 1 186 22 23 0.2 4 10.5 1 0.8 164 6.5 316 80 3.418 3.44 96 28.1 139 2 1.8 1 85.7 170.9 4 4020 MTX 3/10/1994 46 Female 2 8/1/1988 -9 -9 1 1 1 1 1 84 22 26 0.7 4 10.7 1 0.7 160 6.3 194 106 3.617 4.14 117 31.2 150 2 1.6 0.6 66.2 165.1 4 4021 Placebo 5/2/1996 63 Female 3 1/21/1987 -9 -9 1 1 1 1 1 264 57 47 0.5 3.8 9.8 0.9 0.8 194 6.3 113 63 3.869 2.38 93 13.6 77 2 3 2 46 152.4 4 4022 MTX 8/25/1994 44 Female 3 7/3/1991 -9 -9 1 2 2 2 1 216 21 24 0.4 3.8 9.5 0.9 0.8 222 6.3 172 68 2.898 3.61 97 25.9 121 2 1.2 0.2 69.9 167.59 4 4023 Placebo 9/8/1994 40 Female 3 4/30/1991 4 12 1 2 1 1 1 534 62 63 0.5 3.6 11.4 1 0.7 280 3.7 150 84 3.508 3.11 87 17.2 81 2 3 1.75 81.6 162.6 4 4025 Placebo 9/22/1994 32 Female 3 1/28/1994 4 4 1 1 1 1 1 72 31 18 0.4 3.9 12 1.1 0.5 190 5 304 131 2.921 3.17 87 17 79 2 2.6 1.6 66 156.2 4 4026 MTX 4/27/1995 51 Female 2 10/17/1991 -9 -9 1 1 2 1 1 366 80 129 1.2 3.7 8.7 0.8 0.6 282 6.3 213 99 3.986 2.81 85 12.3 62 2 2.2 1.2 73.3 165.1 4 4027 MTX 11/4/1994 46 Female 2 3/7/1994 4 5 1 1 1 1 1 101 27 20 0.4 3.8 11.3 1 0.9 190 5.6 190 86 3.389 4.67 113 22.4 101 2 1.75 0.75 67.8 177.8 4 4030 MTX 5/9/1996 39 Female 2 6/4/1993 4 8 1 1 1 1 1 127 24 30 0.4 4.1 9.7 0.9 0.6 249 7.1 319 132 2.561 2.46 79 12 60 2 2 1 67.1 154.89 4 4032 Placebo 9/29/1994 37 Female 2 1/25/1994 4 5 1 1 1 1 1 149 23 13 0.5 4.3 10.5 1 0.7 233 6.9 405 136 2.745 4.24 103 21.2 93 2 1 0 82.8 172.69 4 4033 MTX 3/16/1995 52 Female 3 9/1/1991 8 4 1 2 1 1 1 171 52 63 0.4 3.6 9.4 0.9 0.6 220 4.9 149 106 3.322 2.94 96 14.3 74 1 3.25 2.25 53.5 157.5 4 4034 Placebo 3/2/1995 43 Female 2 4/12/1994 8 5 1 1 1 1 1 241 27 23 0.2 3.8 9.5 0.9 1.2 313 7.9 288 80 2.256 4.06 112 16.2 76 1 1 0 67 164.6 4 4035 MTX 10/27/1994 52 Female 1 11/11/1993 8 12 1 2 1 1 2 178 25 28 0.3 4.1 11.1 1 1.1 197 6.6 267 95 3.997 3.79 123 22.1 106 2 1.4 0.6 87.1 170.21 4 4042 Placebo 7/27/1995 61 Female 4 11/25/1994 -9 -9 1 1 1 1 1 601 72 64 0.6 4 9.6 0.9 0.6 281 5.3 246 83 3.81 2.62 93 14.7 80 2 3.4 2.6 78.5 157.51 4 4045 Placebo 4/13/1995 41 Female 2 9/27/1994 12 8 1 1 2 1 1 1097 130 97 0.4 3.7 10.7 1 0.8 557 4.3 204 81 3.132 3.17 86 12.8 60 2 2.2 1.2 64.8 165.1 4 4047 MTX 7/20/1995 47 Female 2 9/9/1988 -9 -9 1 1 1 1 1 243 46 35 0.1 3.9 10.6 1 0.7 263 5.6 294 98 2.003 3.07 93 16.7 83 2 2.4 1.4 73.6 159.99 4 4048 MTX 6/29/1995 47 Female 3 12/9/1994 8 6 1 1 1 1 2 114 46 30 0.1 3.9 10.1 1 0.8 175 5.9 273 101 2.318 3.3 97 20.2 99 2 2.2 1.2 64 164.11 4 4054 Placebo 8/17/1995 61 Female 4 11/17/1994 -9 -9 1 1 1 1 1 116 66 44 0.6 4.1 10.9 1.1 1.1 177 6.1 161 67 4.05 2.54 72 15 75 2 2.8 2 77 172.69 4 4057 MTX 9/7/1995 41 Female 3 1/3/1995 -9 -9 1 1 1 1 1 236 41 31 0.5 3.8 9.2 0.9 0.7 170 5.6 226 94 2.899 3.18 100 17.2 85 2 1.8 0.8 66 146.1 4 4060 MTX 11/9/1995 42 Female 2 1/3/1995 -9 -9 1 1 1 1 2 311 40 43 0.3 3.8 9.3 0.9 0.7 207 6.7 142 93 2.949 3.56 89 18 82 2 1 0 69 172.01 4 4061 MTX 10/12/1995 43 Female 3 11/9/1994 -9 -9 1 1 2 1 1 123 24 15 0.1 4 9.8 0.9 0.8 173 7 306 99 1.596 2.95 94 19.2 96 2 2.4 1.4 43.3 155.7 4 4062 Placebo 11/30/1995 49 Female 2 1/3/1995 -9 -9 1 1 1 1 1 143 38 35 0.4 4.2 9.8 0.9 0.8 201 6.9 342 72 2.914 4.46 117 20.9 98 2 2 0.75 84.1 177.5 4 4067 MTX 4/11/1996 61 Female 3 6/2/1995 8 8 1 1 1 1 1 167 22 27 0.3 4.2 9.6 0.9 0.8 210 10.6 297 61 3.083 3.06 106 14.5 79 2 3 2 61.2 157.51 4 4068 Placebo 3/19/1996 51 Female 1 2/1/1995 8 16 1 1 1 1 1 113 16 20 0.4 4.1 9.8 0.9 0.8 247 6.5 288 63 3.053 2.8 88 16.8 85 2 1.5 0.5 73.9 159.99 4 4069 MTX 3/7/1996 49 Female 4 5/9/1995 8 4 1 2 1 1 1 122 78 88 0.4 3.8 9.8 0.9 0.7 188 3.4 93 190 3.167 3.39 103 17.9 89 1 2.75 2.5 77.6 159.99 4 4070 Placebo 3/28/1996 52 Female 3 6/5/1995 4 8 1 1 1 1 1 126 28 40 0.2 4 9.7 0.9 0.7 239 5.7 220 95 2.527 2.76 102 16.5 90 2 2 1 82.1 149.9 4 4072 Placebo 7/24/1996 50 Female 3 7/15/1995 8 16 2 1 1 1 1 277 56 47 0.1 3.8 8.9 0.9 0.9 206 5.5 178 97 1.77 2.52 73 11.6 57 2 3 2 64 165.1 4 4078 MTX 12/5/1996 53 Female 4 8/14/1991 -9 -9 2 1 2 1 1 262 64 59 0.7 3.8 9.3 0.9 1.1 359 5.1 203 66 3.686 3.08 90 15.7 77 1 3.25 2.25 76.7 164.11 4 4079 MTX 10/17/1996 65 Female 3 8/4/1993 -9 -9 2 2 1 1 2 144 46 41 0.9 3.4 13 1.3 0.8 199 5.1 169 97 6.311 2.85 92 17.4 93 1 3.25 2.25 97.5 167.6 4 4080 Placebo 12/5/1996 58 Female 3 6/1/1993 -9 -9 2 1 1 1 1 592 100 126 0.4 3.8 9.6 0.9 0.8 249 7.2 206 71 3.469 4.13 126 19.8 104 2 2 1.25 68.9 170 4 4081 Placebo 12/5/1996 36 Female 2 1/2/1996 -9 -9 1 1 1 1 1 66 54 46 0.8 4.1 9.4 0.9 0.9 192 7.2 304 132 2.973 4.21 119 22.5 105 2 1.5 0 78.5 160 4 4082 MTX 12/5/1996 54 Female 2 3/12/1996 4 5 1 1 1 1 1 214 47 50 0.2 3.8 9.6 0.9 0.8 216 7.2 317 85 2.71 3.66 110 18.9 95 2 2 1 50.8 164.01 4 4083 MTX 1/16/1997 56 Female 2 10/1/1990 -9 -9 1 1 1 1 1 499 77 69 0.3 4 8.5 0.8 0.7 397 6 359 108 2.721 3.97 117 17.9 89 2 2 0.75 78.9 170.21 4 4084 Placebo 2/6/1997 47 Female 3 2/1/1996 4 4 1 1 1 1 1 139 37 45 0.1 3.9 8.9 0.9 0.6 248 5.6 165 118 1.587 3.18 93 18.3 90 2 2.75 2 74.8 162.1 4 4085 Placebo 1/9/1997 26 Female 2 5/1/1996 5 7 1 1 1 1 1 222 74 134 0.8 3.5 9.3 0.9 0.7 251 7.5 336 118 2.958 4.25 100 17.5 74 2 2.5 1.75 85.3 173.51 4 4087 MTX 3/13/1997 45 Female 4 7/17/1996 4 4 1 1 1 1 1 65 28 26 0.4 4.1 9.1 0.9 0.8 181 5.8 269 108 2.643 3.91 108 18.7 88 2 1 0 64.9 168.4 4 4090 Placebo 6/19/1997 64 Female 4 1/1/1991 8 8 2 1 1 1 1 118 37 32 0.5 3.9 11.2 1.1 1.2 186 4.3 135 61 4.199 2.46 76 16.3 86 1 4 3 95 167.6 4 4091 MTX 5/15/1997 63 Female 2 10/25/1996 8 4 1 1 2 1 1 123 20 27 0.2 4.1 9.4 0.9 0.7 278 6.9 319 77 2.818 2.36 92 11.7 67 2 2 1 65 154.9 4 4092 Placebo 6/19/1997 57 Female 3 6/23/1994 8 8 2 1 1 1 1 527 72 90 0.3 4.1 8.7 0.8 0.6 319 7.4 344 92 2.753 1.96 84 13.9 81 2 1.5 0.5 66.2 148.2 4 4093 MTX 7/3/1997 55 Female 2 11/20/1996 8 12 2 1 1 1 1 298 92 178 0.3 4 8.4 0.8 1 234 7.3 428 67 2.654 2.82 90 13.3 68 2 1.75 0.75 61.5 165.1 4 4094 MTX 8/7/1997 39 Female 3 11/4/1991 5 7 1 1 1 1 1 933 133 187 0.7 3.7 8.9 0.9 0.5 350 5.8 317 102 3.103 3.09 92 16.4 79 2 2.25 1.25 54 159 4 4095 Placebo 7/24/1997 50 Female 2 12/9/1996 4 4 1 1 1 1 1 177 32 43 0.2 4.1 9.9 1 0.9 191 4.4 174 71 2.435 3.17 99 17.4 88 2 1.5 0.75 66.7 163.3 4 4096 MTX 8/14/1997 63 Female 4 5/25/1993 4 9 1 1 1 1 1 538 76 37 0.5 3.1 10.7 1 0.8 256 5.3 181 72 4.632 2.97 100 15.2 82 1 4 3 66.1 167.4 4 4097 MTX 4/24/1997 45 Female 3 10/3/1996 8 6 2 1 1 1 1 590 75 56 0.6 3.5 9.2 0.9 0.7 309 5.7 176 78 3.422 2.14 72 14 76 2 3 2 62.4 156 4 4100 Placebo 10/30/1997 57 Female 4 5/19/1995 4 4 2 1 1 1 1 329 80 79 0.3 4.1 8.7 0.8 0.7 285 7.8 203 63 2.753 2.68 100 15.5 86 2 4 2.75 68.04 154.6 4 4101 Placebo 11/6/1997 57 Female 1 3/25/1996 4 8 1 1 1 1 1 120 17 24 0.2 4 9 0.9 0.7 214 7 237 156 2.543 2.75 85 19.3 100 2 1 0 90 167.6 4 4106 Placebo 11/6/1997 60 Female 3 5/5/1997 4 4 1 1 1 2 1 242 43 54 0.1 3.9 9.3 0.9 0.7 160 7.3 334 67 2.199 3.37 105 15.3 80 2 2.2 1.2 47 165.6 5 5001 MTX 7/25/1994 42 Female 1 5/19/1989 11 4 1 1 1 1 1 113 35 31 0.7 3.6 11 1 1.4 253 7.9 197 70 3.794 3.77 85 28.7 84 2 1 0 86.8 167.6 5 5002 Placebo 7/25/1994 38 Female 2 1/1/1989 8 16 1 2 1 2 1 474 89 84 1.3 3.7 12.1 1 1 274 4.3 109 87 4.334 3.45 95 28.3 99 1 3.25 2.25 69.4 162.6 5 5003 MTX 8/12/1994 45 Female 2 3/1/1990 7 7 1 1 1 2 1 155 65 48 0.8 4 12 1 0.7 282 9.2 361 154 3.967 2.24 59 16.4 55 2 1.75 1 108 167.6 5 5004 Placebo 8/17/1994 56 Female 2 5/8/1989 7 7 1 1 1 1 1 210 47 -9 0.9 3.9 12 0.9 0.8 216 6 263 79 4.524 2.77 90 18.9 77 2 2 1 64.4 158.8 5 5005 MTX 9/2/1994 54 Female 1 3/1/1988 8 4 1 1 1 1 1 247 50 24 0.5 3.8 12 1 1.2 161 6.3 258 59 4 2.83 91 23.6 91 2 1 0 54.4 160 5 5006 Placebo 10/5/1994 57 Female 1 3/1/1993 4 4 1 1 1 1 1 185 35 17 0.6 3.6 11 0.9 1 238 6.8 272 85 4.205 3.51 99 22.5 80 2 3 2 79.4 167.6 5 5007 Placebo 9/16/1994 57 Female 1 10/1/1992 4 4 1 1 1 1 1 100 66 27 1.3 4.4 11 0.9 0.9 333 7.8 238 99 4.41 2.84 90 23.4 115 1 1 0.2 73.9 152.4 5 5008 MTX 8/23/1994 50 Female 2 3/26/1991 8 4 1 1 1 1 1 221 53 90 0.7 3.9 -9 -0.9 1.1 -9 5.5 165 80 -9 2.82 116 24.3 88 2 1.5 0.25 44.5 152.4 5 5009 MTX 10/21/1994 47 Female 2 5/14/1991 8 16 1 1 1 1 1 397 133 166 1.1 3.9 11 0.9 0.8 399 4.6 192 123 4.141 3.76 88 28.5 85 2 3 2 86 168.9 5 5011 Placebo 11/25/1994 48 Female 2 12/17/1993 8 8 1 1 1 1 1 403 54 46 0.7 4.1 12 1 0.8 198 5.7 264 130 3.906 3.62 99 27.7 78 2 1.25 0.25 74.8 168.9 5 5012 Placebo 1/18/1995 46 Female 2 9/3/1991 8 16 1 1 1 1 1 262 52 51 0.8 4.1 12 1 0.7 271 6.3 282 141 3.944 2.92 90 22.6 84 2 1.25 0.25 90 160 5 5013 MTX 2/1/1995 57 Female 2 10/12/1992 4 8 1 3 1 1 1 378 66 51 0.6 4 11 0.9 1.1 261 6.7 309 58 3.978 3.23 99 26.4 99 2 2 1 74.5 160 5 5014 MTX 5/16/1995 47 Female 2 9/16/1994 4 8 1 1 1 1 1 121 37 34 0.53 3.7 12 0.9 0.9 200 7.2 164 67 3.884 2.67 95 19.9 84 2 1.5 0.75 56.1 160 5 5017 Placebo 6/3/1995 44 Female 1 1/1/1990 8 8 1 1 1 1 1 70 23 20 0.6 3.8 11 0.9 0.9 235 7.4 293 57 3.601 4.04 100 21.5 75 2 1 0 64.4 169 5 5022 MTX 8/21/1995 53 Female 1 11/4/1994 4 8 1 1 1 1 1 212 23 24 0.6 3.8 12.1 1 0.8 245 5.5 411 65 4.178 3.12 101 23.4 91 2 1 0.25 57.6 157.5 5 5023 Placebo 10/26/1995 47 Female 1 1/10/1995 8 4 1 1 1 1 1 265 40 40 0.73 3.7 11 0.9 0.8 249 7.8 216 95 3.956 3.82 99 28.6 99 2 2 0.75 85.3 170.2 5 5024 MTX 11/14/1995 55 Female 3 1/1/1993 8 8 1 1 1 1 1 412 79 105 0.9 3.8 -9 -0.9 0.8 265 4.9 173 74 -9 2.36 81 22.9 93 2 4 3 72.9 154.9 5 5025 Placebo 8/7/1996 47 Female 1 11/1/1995 8 8 1 1 1 1 1 150 30 33 0.6 3.9 12.1 1 0.7 191 6.7 301 115 3.879 3.4 112 26.6 107 2 1 0 79.4 163.1 5 5026 MTX 8/19/1996 38 Female 3 12/28/1994 8 12 1 1 1 1 1 554 56 51 0.8 3.8 11.9 1 0.7 237 5.2 140 142 3.804 3.14 73 26.4 84 2 3 2.25 97.5 177.8 5 5027 Placebo 2/19/1997 66 Female 1 9/26/1994 7 6 1 1 1 1 1 107 21 25 0.9 3.9 12 1 0.9 247 5.4 188 71 5.383 3.35 116 24.1 103 2 1.75 0.75 74.5 162.6 5 5029 Placebo 1/15/1997 40 Female 2 6/1/1996 4 8 1 1 1 2 1 630 119 132 1.2 3.9 12 1 0.7 279 7.3 225 82 4.19 3.37 98 18.2 67 2 2.5 1.5 70.8 162.6 5 5032 MTX 10/7/1997 49 Female 2 2/1/1997 8 4 1 1 1 1 2 155 36 46 0.7 4.2 12.3 1 1 261 9.1 337 71 4.372 2.48 76 21.8 85 2 3 1.75 103 160 6 6001 Placebo 3/18/1994 63 Female 2 12/11/1985 4 12 1 1 1 1 1 170 64 82 0.5 4.2 11.1 1 1 265 6.1 252 78 3.951 2.92 92 24.6 91 1 1.4 0.8 85.1 167.64 6 6002 MTX 3/16/1994 69 Female 2 6/21/1991 5 4 1 1 1 1 1 200 48 43 0.8 4.1 11.9 1 1 222 5.1 252 69 4.821 3.46 126 19.5 85 1 1.8 1 59.9 160.02 6 6004 MTX 4/8/1994 46 Female 4 2/18/1991 8 11 1 1 1 1 1 387 52 57 0.6 4.1 12.1 1 0.9 218 5.2 375 113 3.713 4.4 119 28.4 96 2 1 0 85.3 175.26 6 6005 Placebo 3/25/1994 44 Female 2 5/18/1992 4 4 1 1 1 1 1 180 29 33 0.7 4 12.4 1 1 230 7.1 241 100 3.89 4.31 119 24.1 85 2 1 0 110.2 172.7 6 6006 Placebo 4/22/1994 65 Female 4 12/16/1991 4 5 1 1 1 1 1 135 34 31 0.5 4.1 11.6 0.9 0.8 211 7.9 247 94 4.195 2.91 108 14.6 68 2 2.2 1.4 69.9 157.5 6 6007 Placebo 4/29/1994 47 Female 4 3/9/1990 4 4 1 1 2 2 1 257 49 37 1 3.8 13.9 1 0.9 148 5.7 124 80 5.149 3.12 104 18.9 88 2 MISSING MISSING 51.7 157.5 6 6008 Placebo 2/1/1995 50 Female 1 4/1/1990 4 4 1 1 1 1 1 232 31 31 1.2 3.8 12 1 0.7 193 5.6 169 87 5.075 2.31 81 18.8 93 2 1.2 0.8 65.1 154.94 6 6009 MTX 4/29/1994 58 Male 3 2/2/1989 4 4 1 1 1 1 1 152 45 30 0.8 4.2 12.4 1 0.9 216 5.4 133 119 4.429 4.42 122 26.2 97 1 3.2 2 66.5 167.64 6 6010 Placebo 7/1/1994 51 Female 3 2/14/1992 8 4 1 1 1 1 1 999 223 255 1.7 4.4 12.2 0.9 0.9 368 5.6 219 52 4.656 2.67 95 19.8 98 2 3.6 2.4 49.9 154.9 6 6011 Placebo 5/6/1994 55 Female 4 5/8/1992 9 14 1 2 2 2 1 315 76 72 1.5 4.1 12.1 1 1 249 4 171 75 4.862 3.33 112 18.5 81 1 3.5 2.5 56.7 161.3 6 6012 MTX 5/13/1994 56 Female 1 11/1/1990 4 6 1 1 1 1 1 193 19 25 0.6 4.2 12.7 1 0.9 264 10.1 335 130 4.157 2.73 89 24.9 102 2 1.4 0.2 113.4 162.56 6 6013 MTX 5/27/1994 65 Female 3 12/14/1989 8 4 1 1 1 1 1 152 32 23 0.4 3.8 11 0.9 1.1 217 7.1 241 89 4.066 1.98 77 15.7 78 2 2 1 69.9 154.94 6 6014 Placebo 6/1/1994 55 Male 4 10/8/1987 8 8 1 1 1 1 1 270 86 71 0.9 4 12 1 0.9 307 8.9 162 138 4.889 3.42 97 20.1 78 2 3 2 86.2 165.1 6 6015 MTX 6/10/1994 51 Female 4 6/14/1990 7 11 1 1 1 1 1 236 82 88 1.5 4 11.4 0.9 1 286 5.7 304 84 4.627 3.88 119 24.6 96 2 1.4 0.2 67.6 165.1 6 6016 MTX 6/17/1994 56 Male 4 12/27/1990 12 8 1 2 1 1 1 193 46 67 0.7 4.2 11.8 1 1.2 237 4.9 126 97 4.117 4.88 107 27.6 85 1 3.8 2.8 72.1 177.8 6 6017 Placebo 6/24/1994 61 Female 4 5/15/1991 12 4 1 1 1 1 1 270 42 18 1 3.6 12.3 1 0.9 206 5.6 229 59 5.111 2.03 67 13.1 52 1 3.2 2.2 56.7 162.56 6 6018 Placebo 7/22/1994 58 Female 3 6/26/1992 4 9 1 1 1 1 1 604 119 94 1.3 4.1 12.2 1 0.9 293 4.2 174 105 4.874 2.93 104 20.6 96 1 3.2 2.2 55.6 157.5 6 6019 Placebo 10/7/1994 50 Female 1 8/1/1991 8 4 1 1 1 1 1 276 36 36 0.6 4.5 12.1 1 0.9 224 7.3 341 84 3.634 4.06 119 28.1 104 2 1.2 0.2 83 167.64 6 6021 MTX 2/5/1996 55 Female 3 2/15/1995 7 11 2 1 1 2 1 256 43 32 0.6 4.2 11.3 0.9 1 367 8.1 202 74 3.84 3.35 99 23.7 86 2 3.25 2 102.1 170.2 6 6022 MTX 3/10/1997 39 Female 3 2/26/1996 4 4 1 1 1 1 1 79 21 20 0.5 4 11.4 0.9 0.7 212 8 256 106 3.202 3.82 114 18.2 89 2 1.75 1 60.3 157.48 6 6023 Placebo 10/22/1997 63 Male 3 3/5/1987 4 4 1 1 1 2 1 650 60 61 1.1 4.8 12.1 1 1.3 270 7.8 214 76 4.505 3.24 73 27 82 2 3 1.75 78.9 180.3 6 6024 Placebo 12/15/1997 51 Female 3 2/20/1997 4 4 1 1 1 1 1 148 39 45 0.7 4.1 12.4 1 0.8 268 5.6 231 95 4.101 2.12 75 17.5 87 2 1.75 1 80.1 154.9 7 7001 MTX 10/7/1994 45 Female 3 6/30/1990 4 12 2 1 1 1 1 455 95 202 1.6 4.5 11.7 1 0.9 286 5.7 138 73 4.213 3.83 121 16.5 65 2 2.6 1.6 51.7 157.5 7 7002 Placebo 10/21/1994 64 Female 3 2/15/1988 8 8 1 1 1 2 1 138 52 50 0.5 3.8 11.6 0.9 0.9 259 8.1 405 76 4.348 3.68 113 17.9 71 2 3 2 67.6 165.1 7 7003 MTX 11/4/1994 49 Female 2 5/31/1991 12 8 1 1 1 1 1 97 24 28 0.5 3.9 13 1.2 0.9 192 9.7 164 80 3.969 3.97 111 20.1 73 2 1 0 56.7 167.6 7 7004 Placebo 5/27/1994 39 Female 1 4/10/1992 8 4 1 1 1 1 1 141 20 21 0.4 4.4 11.5 0.9 1 200 4.8 258 78 2.787 4.17 110 16.4 57 2 1.4 0.4 55.3 167.41 7 7005 MTX 4/15/1994 38 Female 2 7/22/1992 4 8 1 1 1 1 1 221 47 68 0.6 6 12 1.1 1 231 7.9 269 106 2.418 4.95 125 28.3 95 2 3 2 76.7 171.5 7 7006 MTX 5/27/1994 44 Female 1 3/11/1993 10 8 2 1 2 2 1 184 38 47 0.5 4.3 11.9 1 0.8 188 6.4 226 66 3.316 4.78 111 27.4 87 2 1.75 0.75 88.5 178.1 7 7007 Placebo 5/23/1994 52 Female 2 8/20/1990 4 8 1 1 1 1 1 117 27 35 0.6 4.5 12 0.9 1.1 201 5.5 310 72 3.692 3.02 96 24.4 83 2 2.8 1.8 83 157.48 7 7008 MTX 6/3/1994 54 Female 3 5/1/1993 16 7 1 1 1 1 1 152 35 27 0.7 3.8 13.1 1.2 1.1 196 5.7 234 59 4.541 2.7 87 15.5 63 2 3.2 2.4 86.2 160.02 7 7009 Placebo 1/6/1995 49 Female 3 4/15/1993 8 8 1 2 2 1 1 282 78 72 2.4 3.7 13.8 1.3 1 190 5.7 206 92 5.61 3.18 85 15.4 54 2 MISSING MISSING 85.3 159.5 7 7011 Placebo 12/2/1994 28 Female 1 2/26/1994 7 7 1 1 1 1 1 255 58 69 0.7 4.3 12.3 0.9 0.8 217 6.4 222 111 3.064 5.32 124 28.8 91 2 1 0 65.3 172.7 7 7012 Placebo 10/28/1994 47 Female 3 8/15/1993 8 8 1 1 1 1 1 108 24 29 0.4 4.2 11 0.8 0.9 222 7 274 104 3.111 3.63 109 27.7 79 2 1 0 93 163.83 7 7013 MTX 11/18/1994 42 Female 3 10/1/1993 8 4 1 1 1 1 1 247 36 36 0.5 4 12.1 1 0.9 183 3.7 248 105 3.461 4.34 125 27.5 103 2 3 1.6 90.3 172.69 7 7014 Placebo 12/16/1994 60 Female 3 8/1/1992 4 4 1 1 1 1 1 326 32 29 0.5 4.2 11.7 0.9 1.2 178 6.2 182 78 3.959 3.19 117 15.2 67 2 4 1 54 152.7 7 7015 MTX 12/16/1994 50 Female 3 11/1/1987 12 9 1 1 1 1 1 132 78 123 1.3 4.2 12.2 1 0.9 213 5.8 189 71 4.501 3.61 101 21.3 78 2 2.67 2.33 78.9 166.9 7 7023 MTX 12/22/1995 45 Female 2 3/3/1985 8 8 2 1 1 1 1 190 29 44 0.4 4.4 11.5 0.9 1 319 8.5 252 91 3.021 3.01 95 21.4 84 1 2.8 1.6 85.3 157.7 7 7029 MTX 2/24/1995 47 Female 3 8/1/1990 8 11 1 1 2 1 1 119 39 63 0.3 3.8 11.2 0.9 0.8 202 4.2 242 105 3.157 3.34 121 16.3 70 2 1.4 0.4 59.4 154.9 7 7033 Placebo 5/12/1995 49 Male 2 8/30/1994 4 4 1 1 1 1 1 111 22 36 0.94 4.2 11.3 0.9 1 176 6.2 355 132 3.997 5.04 90 33.8 82 2 1.4 0.6 103 187.96 7 7035 MTX 6/23/1995 52 Female 1 1/1/1980 5 6 1 1 1 1 1 306 39 37 0.5 4.1 -9.9 -0.9 0.8 250 5.6 282 100 -9 3.09 95 17.3 68 2 1.8 1 73.5 162.6 7 7036 MTX 7/21/1995 51 Female 2 6/1/1989 8 8 1 1 2 1 1 467 72 87 1.8 4.1 12.3 1.1 0.9 288 3.6 150 89 4.904 3.95 101 10.1 62 1 3 1.8 65.32 175.8 7 7039 MTX 8/11/1995 52 Female 2 3/1/1994 11 4 1 1 1 1 1 84 23 22 0.4 3.8 11.1 -0.9 0.9 159 7 297 90 3.581 3.28 100 16.1 62 2 1.2 0.6 73.5 162.6 7 7040 Placebo 2/2/1996 52 Female 2 5/5/1995 5 5 1 1 1 1 1 289 40 48 0.3 3.8 11.5 0.9 0.9 223 4.6 328 74 3.415 3.06 101 24.3 100 2 2 0.75 61.7 155.4 7 7042 MTX 11/22/1996 41 Female 3 12/1/1994 8 4 1 1 1 1 1 224 39 -9 0.5 4.5 11.5 0.9 1 -9 6.1 228 136 3.003 3.37 96 25.4 93 2 1.75 0.75 76.2 160 7 7043 Placebo 9/6/1996 55 Male 4 7/1/1995 4 4 1 1 1 1 1 206 34 57 1 3.8 12.5 1.1 1 198 6.6 191 144 4.779 4.47 87 40.9 109 2 3.5 2.5 95.3 185.4 7 7044 MTX 9/6/1996 67 Male 3 1/2/1996 4 8 1 1 2 1 1 106 22 20 0.6 4.2 11 0.9 1.2 270 3.9 226 64 4.244 4.43 100 18.1 57 2 MISSING MISSING 69.6 172.7 7 7045 Placebo 1/31/1997 36 Female 3 1/13/1996 12 8 2 1 1 1 1 406 55 63 0.5 3.6 11.1 0.9 0.8 279 9.4 243 125 3.288 2.35 73 15.2 58 2 1.5 0.75 95.7 162.6 7 7047 Placebo 10/17/1997 66 Female 1 1/1/1984 8 8 1 1 1 1 1 118 25 24 0.9 4.2 11.4 0.9 1 242 5.3 314 130 4.643 2.93 99 22.3 94 2 1 0 66.7 158.8 7 7048 Placebo 8/1/1997 49 Female 4 3/1/1995 8 8 1 1 1 1 1 546 149 138 1.3 3.4 11.7 1 0.7 257 5.5 218 75 4.897 3.33 117 15.8 67 1 4 3 53.1 151.1 7 7501 Placebo 11/9/1994 57 Female 1 10/1/1992 8 4 1 1 1 2 1 116 15 12 0.6 3.7 11.3 0.9 0.8 218 10.2 224 97 4.239 2.5 73 14.5 63 2 1 0 110.5 169.2 7 7503 Placebo 5/17/1994 46 Female 3 1/1/1989 4 8 1 1 1 1 1 76 26 26 0.8 4.3 13.2 1.2 0.8 227 5.1 198 83 4.05 3.87 103 26.3 92 2 3 2 76.7 170.4 7 7504 Placebo 1/16/1995 46 Female 2 3/1/1989 8 11 1 1 1 1 1 102 26 35 0.4 4.3 11.9 1 0.7 264 8 411 92 3.2 3.55 108 21.3 78 2 2 0.6 67.2 162.3 7 7505 Placebo 1/10/1995 39 Female 1 4/1/1994 5 4 1 1 1 1 1 99 21 18 0.3 3.9 11 0.9 0.5 212 6.6 389 139 2.736 4.29 147 21.4 88 2 1.2 0 65.9 149.4 7 7506 MTX 2/23/1995 45 Male 3 10/1/1990 5 8 1 1 1 1 1 118 23 27 0.5 4 11.6 1 0.7 208 7 403 122 3.438 4.65 101 23.9 69 2 2.6 1.6 57.8 170.9 7 7508 MTX 3/16/1995 43 Female 3 2/2/1994 5 4 1 1 1 1 1 53 15 13 0.3 4.5 11 0.9 0.9 263 6.7 318 111 2.53 3.93 113 23.1 82 2 2.2 1.4 82.1 164.6 7 7509 MTX 3/7/1995 48 Female 2 2/18/1994 4 4 1 1 1 1 1 115 14 13 0.2 3.5 12.4 1.2 0.7 190 9.8 428 87 3.254 4.07 107 22.4 74 2 2.2 1.6 62 170.7 7 7510 MTX 4/24/1995 63 Female 4 6/1/1994 8 12 1 1 1 1 1 127 44 43 0.7 3.6 11.7 1 0.7 167 5.5 165 88 5.189 3.19 126 16.2 75 1 4 2.8 64.1 154.2 7 7511 Placebo 6/7/1995 56 Female 4 1/1/1990 8 4 1 1 1 1 1 312 47 41 0.9 3.9 12 1.1 0.6 218 4.6 148 107 4.563 2.87 98 20.9 88 1 4 2.6 69.4 160 7 7512 Placebo 8/15/1995 51 Female 4 9/13/1994 8 8 1 1 1 1 1 200 40 29 0.9 3.6 12.1 1.1 0.8 146 7.6 162 90 4.59 3.63 115 16.4 65 2 4 2.6 79.7 162.1 7 7514 Placebo 9/20/1995 54 Female 1 10/1/1993 4 4 1 1 1 1 1 107 23 21 0.4 3.8 10.9 0.8 0.8 261 4.3 194 76 3.616 3.85 128 24.9 87 2 1.8 1 87.8 174.2 7 7515 MTX 5/18/1995 45 Female 1 10/1/1993 -9 -9 1 1 2 1 1 218 32 36 0.4 3.9 11.1 0.9 0.7 226 6.1 270 94 3.242 3.44 109 19.1 75 2 1 0 57.5 159 7 7516 MTX 6/13/1996 45 Female 2 5/24/1995 12 4 2 1 1 1 1 130 29 28 0.4 3.9 -9 -0.9 0.7 193 7 292 60 -9 2.62 81 21.2 79 2 1.25 0.25 80.3 163.1 7 7517 Placebo 7/22/1996 65 Female 3 4/29/1992 4 4 1 1 1 1 1 77 19 21 0.4 3.5 12 0.9 0.8 -9 8.8 240 76 4.481 2.91 106 24.4 105 2 3.25 2 72 158.5 7 7518 MTX 10/24/1996 64 Male 1 12/18/1995 4 8 1 1 1 1 1 180 27 22 0.2 3.7 14.5 1.2 1 278 10.1 360 77 4.149 4.6 98 19.4 58 2 1.75 1 77.5 179.1 7 7519 MTX 1/30/1997 42 Female 3 4/11/1996 4 4 1 1 1 1 1 223 38 33 0.6 4.4 12.3 0.9 -0.9 258 4.6 225 112 3.378 3.64 88 22.1 73 2 2.25 1.5 91.2 172.7 7 7522 Placebo 10/10/1996 63 Female 2 6/5/1995 4 4 1 1 1 1 1 99 39 30 0.5 3.9 12.8 1 0.8 183 5.8 212 74 4.478 2.84 112 17.5 79 2 MISSING MISSING 60.4 153.9 7 7523 MTX 7/25/1997 52 Male 3 10/1/1996 8 4 1 1 1 1 1 180 55 81 0.5 4.4 12 0.9 0.9 271 11.2 543 166 3.59 4.51 87 37.8 100 2 2 1 95.3 179.6 7 7529 MTX 3/17/1998 32 Female 2 5/1/1997 8 12 1 1 1 1 1 569 108 149 0.7 4.3 13 1 0.5 280 4.7 173 165 3.352 4.32 113 26.7 91 2 1 0 55.5 165.1 7 7703 Placebo 7/23/1997 60 Female 2 11/1/1984 4 4 1 1 1 1 1 333 35 41 0.7 4.4 12.1 1 0.6 242 9.4 266 171 4.176 2.82 87 16.3 62 2 2.25 1 67 165.1 8 8001 MTX 6/28/1994 58 Male 2 2/15/1989 4 4 1 2 1 1 1 220 63 45 0.8 3.8 11.7 0.9 1.4 180 5.2 122 59 4.544 4.31 94 23 77 1 2.2 1.2 67.2 172.7 8 8002 Placebo 7/19/1994 42 Female 2 10/20/1992 10 11 1 1 2 1 1 1130 107 311 0.8 4.1 11.3 0.8 1.2 379 11.8 558 53 3.645 4.6 102 13.3 59 2 2.2 1.4 51.7 149.9 8 8003 MTX 7/26/1994 38 Female 2 6/17/1993 4 4 1 1 1 1 1 206 24 30 0.4 4.2 11.1 0.8 1 192 6.6 209 92 2.782 4.58 106 28.8 92 2 1.2 0.6 82.6 175.79 8 8004 Placebo 7/12/1994 42 Female 2 12/15/1990 5 4 1 1 1 1 1 79 72 77 0.4 4.3 12 1 1.2 188 6.8 169 71 3.064 3.58 102 22.4 95 2 1.8 0.8 89.8 162.5 8 8006 MTX 9/27/1994 39 Male 2 2/10/1993 11 16 1 1 1 1 2 476 34 48 0.7 4 11.4 0.9 1.1 437 9.2 260 85 3.886 6.49 124 30.8 64 1 1 0.2 76.3 177.8 8 8007 MTX 2/21/1995 51 Female 3 3/16/1992 8 16 1 1 1 1 1 165 97 114 1.3 3.7 12.8 1.2 0.7 171 3.9 94 89 5.405 3.6 99 19.9 88 1 3.8 2.6 66.5 162.6 8 8008 Placebo 10/18/1994 47 Female 2 1/1/1987 4 4 1 1 1 1 1 146 29 31 0.5 3.5 13 1.3 1 125 5 341 67 4.164 4.32 115 22.6 94 2 1.4 0 83.5 167.6 8 8009 Placebo 1/3/1995 52 Female 3 2/16/1993 4 5 1 2 1 1 1 206 53 22 1.1 3 12.6 1.1 0.7 138 3.4 80 85 5.323 2.51 74 14 60 1 3.2 2 65.3 165.1 8 8010 MTX 9/12/1995 52 Female 2 11/10/1994 4 8 1 1 1 2 1 161 34 41 0.8 4 11.5 0.8 1 267 8.1 427 55 4.139 3.61 111 17.1 76 2 1.8 0.8 51.3 159.99 8 8017 MTX 9/12/1995 59 Female 4 1/16/1995 4 8 1 1 1 1 1 434 133 186 1.8 3.9 11.5 0.8 0.7 311 4.9 190 181 5.573 3.16 108 18.6 82 2 3.2 2 50.8 157.51 8 8020 MTX 10/10/1995 40 Female 3 1/30/1995 4 12 1 1 1 1 1 443 73 97 0.8 4.5 12.3 0.9 0.8 244 4.8 349 91 3.533 3.87 109 20.6 85 2 1 0.2 65.9 160 8 8021 Placebo 12/19/1995 47 Female 2 2/27/1993 8 4 1 1 1 1 1 216 28 24 0.7 4 11.8 0.9 1 188 4.3 183 167 3.889 4.02 110 17.9 75 2 2 0.8 60.6 170.2 8 8022 Placebo 1/23/1996 47 Female 2 4/22/1994 4 4 1 1 1 1 1 71 26 16 0.7 4.1 13.6 1.1 0.6 154 6 243 411 4.165 3.66 99 20.6 85 2 1.5 0.5 51.3 167.59 8 8025 Placebo 7/23/1996 60 Female 2 11/20/1995 4 20 1 1 1 1 1 87 26 26 0.5 4 12.2 0.9 0.5 220 6.1 242 228 4.182 2.73 100 16.8 60 2 2.75 1.75 87.9 157.5 8 8026 MTX 8/27/1996 47 Female 4 7/14/1992 8 11 1 2 1 1 1 173 68 59 1.1 3.4 13.4 1.1 0.8 172 3.8 89 91 4.997 3.72 96 15.3 61 1 3.25 2.25 92.5 170.2 8 8027 MTX 10/7/1996 50 Female 2 9/26/1995 5 4 1 1 1 1 1 537 58 52 2.1 3.8 13 1 0.7 182 5.8 139 100 5.323 2.95 93 20.3 93 2 2.5 1.5 64.7 154.9 8 8033 MTX 5/30/1994 45 Female 2 2/15/1991 4 16 1 1 1 1 1 271 111 168 0.7 3.7 11 0.9 0.9 263 5.4 187 99 3.841 3.65 105 20.2 79 2 1 0.6 64.4 167.6 8 8035 MTX 11/4/1997 48 Female 2 9/24/1996 9 11 1 1 1 1 1 150 18 38 0.3 3.4 12.7 0.9 1 224 7.5 295 75 3.776 3.18 88 20.7 87 2 1 0 92.5 166.4 9 9002 MTX 3/30/1995 58 Female 2 8/5/1992 10 8 1 1 1 1 1 162 23 47 0.4 4.6 11.3 0.9 0.8 307 6.3 394 88 3.374 3.6 120 23.2 100 2 1.6 1 73 161.3 9 9004 Placebo 1/4/1996 57 Female 2 2/21/1992 11 8 1 1 1 1 2 240 36 37 0.8 3.9 11.6 1 0.9 289 7.2 186 89 4.848 3.4 103 22.1 82 2 3.2 1.8 149.7 168.9 9 9005 Placebo 7/20/1995 62 Female 2 10/15/1991 4 8 1 2 1 1 1 142 21 30 0.8 4.7 11.8 1 0.9 230 9.5 256 87 4.182 2.7 100 18.4 91 2 1.8 0.8 63.1 157.5 9 9007 MTX 6/22/1995 51 Female 3 12/5/1989 5 8 1 1 1 1 1 392 92 61 2.2 4 11.9 1.1 0.6 262 3.4 116 96 5.024 3.5 113 19 81 2 3.6 2.2 67.6 160 9 9008 Placebo 4/10/1997 53 Female 1 3/11/1994 8 4 2 1 1 1 1 120 36 45 0.6 4.4 11.5 0.9 0.6 246 6.4 237 80 3.647 2.9 100 17.6 82 2 1 0 60.1 154.9 9 9010 Placebo 5/11/1995 61 Female 2 4/1/1991 8 4 2 1 1 1 1 197 23 38 0.6 4.3 11 0.9 0.9 323 7.4 297 65 3.951 2.5 86 18.3 91 2 2.6 1.6 71.2 161.3 9 9013 MTX 6/8/1995 54 Female 2 1/1/1990 11 11 1 1 1 1 1 311 46 48 0.7 3.8 11.5 1 0.7 251 4 182 84 4.192 3.5 125 19.1 77 2 1.8 0.6 51.9 154.9 9 9014 Placebo 4/13/1995 52 Female 1 7/6/1990 10 4 1 1 1 1 1 79 17 22 0.64 4.5 11.8 1 0.8 342 7.4 262 86 4.138 2.8 90 20.1 101 2 1.4 0.8 66.2 162.6 9 9015 MTX 7/20/1995 41 Female 2 11/14/1994 12 14 1 1 1 1 1 523 116 171 1 4.1 11.5 1 0.7 271 4.8 123 94 3.842 3.4 117 22.8 82 2 3 2 49 152 9 9016 Placebo 10/26/1995 53 Female 3 2/22/1994 4 4 1 1 1 1 1 168 28 26 0.9 4 13.4 1.1 1 231 5.5 163 63 4.645 2.2 76 18.4 101 2 4 2.6 58.8 159 9 9017 MTX 3/28/1996 49 Female 1 8/1/1994 6 5 1 1 1 1 1 55 14 32 0.5 4.1 12.5 1.2 0.8 168 4.6 179 109 3.749 3.7 97 27.8 105 2 1.5 0.5 64.9 173 9 9018 Placebo 4/25/1996 49 Female 1 1/1/1987 4 4 1 2 1 1 1 131 41 23 1.9 3.1 12.5 1.2 0.9 201 5 97 69 6.048 2.8 88 16.9 79 2 1 0.25 85.2 160 9 9019 MTX 8/1/1996 36 Female 1 12/1/1995 -9 -9 1 1 1 1 1 88 22 23 0.5 4.4 11.8 0.9 0.7 245 6.5 285 97 2.887 3.7 103 17.7 66 2 1.5 0.5 62.6 150.1 9 9021 Placebo 9/12/1996 48 Female 1 9/12/1995 12 18 2 1 2 1 1 168 14 16 0.4 3.6 11.8 0.9 0.8 231 8.1 257 82 3.707 3.2 86 21.7 94 2 2 0.75 96.1 168.9 9 9022 MTX 9/12/1996 65 Female 2 10/1/1987 4 8 1 1 1 1 1 191 38 31 0.8 3.9 12.2 1 0.8 238 9.6 233 73 4.812 3.2 110 21.8 102 2 2.5 1.5 53.1 161 9 9023 MTX 11/7/1996 66 Female 3 1/1/1982 4 4 1 1 1 1 1 241 42 40 0.8 4.2 10.7 0.8 0.8 245 5.4 176 103 4.39 4 118 19.9 77 2 3 2 77.1 172.7 9 9025 MTX 7/3/1997 59 Female 1 2/28/1996 -9 -9 1 1 1 1 1 221 19 12 0.4 4.1 11.8 0.9 0.8 260 6 255 131 3.807 3.2 100 23.2 85 2 1 0 74.5 165.1 9 9026 Placebo 5/22/1997 60 Female 3 6/13/1996 -9 -9 1 1 1 1 1 403 58 64 0.9 4.1 11.7 0.9 0.8 265 3.8 125 80 4.532 3.2 114 21.1 99 2 3 2 90.3 157 9 9027 MTX 4/10/1997 68 Female 2 5/1/1996 10 12 1 1 1 1 1 233 35 21 0.8 4.2 12.1 1 0.8 209 6.2 182 68 4.761 3 142 12.2 81 2 2.5 1.75 53 152.4 9 9028 Placebo 5/22/1997 47 Female 1 12/1/1995 7 8 1 1 2 1 1 82 115 47 1.3 3.8 11.8 0.9 0.7 195 5.4 122 85 4.558 2.6 95 16.7 99 2 3 1.75 66 157 9 9030 Placebo 9/11/1997 59 Female 4 9/15/1996 12 4 1 1 1 1 2 100 81 58 1.5 3.6 11.7 1 1.1 239 6.6 132 90 5.697 2.9 97 20.2 105 2 4 3 107 160 9 9035 MTX 3/2/1994 55 Female 2 8/9/1985 8 12 1 1 1 1 1 269 58 67 0.6 3.7 11 0.8 0.9 167 11.8 352 78 4.097 2.89 109 13.3 63 2 1.6 0.6 49 152.4 10 10001 Placebo 5/22/1997 53 Female 3 10/15/1992 4 4 1 1 1 1 1 101 29 38 1.3 4.4 10.4 0.9 0.7 214 5.8 198 120 4.121 3.54 105 17.9 76 2 1.75 0.75 80.7 165.1 10 10002 MTX 11/7/1996 45 Female 2 11/9/1995 -9 -9 1 1 1 1 1 113 32 48 0.7 4.4 10.5 0.9 1 263 9.1 334 83 3.292 3.5 106 21.5 99 2 1.25 0.5 68.3 157.5 10 10003 MTX 5/22/1997 42 Female 3 3/29/1993 8 8 1 1 1 1 1 225 33 36 0.4 4.6 9.6 0.9 0.8 206 10.7 275 103 2.362 4.66 115 20.4 95 2 1.75 0.5 60.4 175.3 10 10004 Placebo 5/22/1997 65 Female 2 5/31/1991 9 9 2 1 1 1 1 112 28 17 0.5 3.8 9.5 0.9 -0.9 211 7.1 253 90 4.341 2.4 81 15.2 67 2 3 1.75 89.3 165.1 10 10006 Placebo 7/3/1997 53 Female 3 12/15/1991 -9 -9 1 1 2 1 1 442 118 129 1.2 4.2 10.2 0.9 0.5 375 3.7 159 107 4.122 2.49 80 19.2 117 2 1 0.5 46.8 161 10 10007 Placebo 7/3/1997 61 Female 2 9/15/1988 4 11 1 1 1 1 1 380 35 40 0.4 3.9 9.4 0.9 0.9 327 12.6 328 58 3.471 3.84 126 16.9 88 2 1 0.25 62.2 162.6 10 10008 MTX 7/3/1997 49 Female 3 1/1/1991 4 16 1 1 1 1 1 226 41 29 0.6 4.2 10.5 0.9 0.7 221 6.2 231 116 3.432 3.58 107 19.8 84 2 2 1 76.4 162.6 10 10010 MTX 10/30/1997 54 Female 2 3/26/1997 4 5 1 1 1 1 1 169 44 32 0.7 4.3 9.9 0.9 0.5 209 5.3 227 172 3.561 3.54 92 21.8 81 2 1.75 0.75 73.1 168.9 10 10013 MTX 2/12/1998 52 Female 3 7/24/1997 -9 -9 1 1 1 1 1 718 132 154 1.8 4.4 10.4 0.9 0.7 284 7.6 373 124 4.365 3.04 114 20.6 108 2 MISSING MISSING 58.5 157.5 11 11007 Placebo 3/28/1996 62 Female 3 1/1/1984 4 4 1 1 1 1 1 229 66 38 0.3 4.3 11.5 1 0.9 -9 3.6 142 83 3.492 3.4 126 14.8 83 2 MISSING MISSING 59 154.9 11 11019 MTX 3/16/1994 67 Female 3 4/25/1989 4 4 1 1 1 1 1 173 40 46 0.6 3.7 12 0.9 0.8 209 6.8 172 90 4.772 2.95 106 16.6 81 2 3.2 2.2 58.2 159.5 11 11020 Placebo 7/20/1997 56 Female 3 12/1/1993 9 8 1 1 1 1 1 322 36 58 0.5 3.9 10.4 0.9 0.8 209 9 292 107 3.71 2.79 84 23.5 126 2 3 2 81.2 167.64